Tuesday, July 10, 2012

Lipid helps cells find their way by keeping their 'antennae' up

Monday, July 9, 2012

A lipid that helps lotion soften the skin also helps cells find and stay in the right location in the body by ensuring they keep their "antennae" up, scientists report.

Each cell has an antenna, or cilium, that senses the environment then determines where to go and what to do when it arrives, said Dr. Erhard Bieberich, biochemist at the Medical College of Georgia at Georgia Health Sciences University.

"A cell is blind; it does not see, it does not feel; it doesn't know where it is," Bieberich said. "It needs to have an organelle that senses where it is in space in order to go where it wants and needs to go."

That kind of direction helps keep brain cells, for example, from wandering off to the feet and vice versa. It's enabled by growth factor receptors on the antennae that are attracted to growth factors secreted by cells that already have found their way. Once cells are situated, the antennae help them respond to nearby signals, such as helping kidney cells sense when to void, said Bieberich, corresponding author of the study in Molecular Biology of the Cell.

His team has shown that the lipid ceramide helps cells keep this organelle or antenna from retracting by inhibiting the enzyme, histone deacetylase 6 or HDAC6.

Antennae must retract for cells to divide and activating HDAC6 enables that occasional necessity, such as during development or when more skin or gastrointestinal cells are needed to replace normal turnover. Interestingly, some of the most rapidly dividing cells, cancer cells, "abuse" HDAC for their purposes; they also suppress ceramide, which is known to induce cell suicide, Bieberich said.

Ceramide is really quite the multi-tasker. Bieberich's team reported in 2007 in the Journal of Biological Chemistry that in the earliest days of development, it helps orient stem cells to which way is up and find their place in a lineup that is important for the genesis of an embryo. Three years earlier the scientists showed the lipid teams up with the protein PAR-4 to eliminate useless cells in developing brains.

###

Georgia Health Sciences University: http://www.georgiahealth.edu

Thanks to Georgia Health Sciences University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/121549/Lipid_helps_cells_find_their_way_by_keeping_their__antennae__up

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Monday, July 9, 2012

Flooding exposes deep distrust of Russia's leaders

A local resident stands at a flooded house in Krimsk, about 1,200 kilometers (750 miles) south of Moscow, Russia, Sunday, July 8, 2012. The death toll from severe flooding in the Black Sea region of southern Russia has risen to at least 150. (AP Photo/Ignat Kozlov)

A local resident stands at a flooded house in Krimsk, about 1,200 kilometers (750 miles) south of Moscow, Russia, Sunday, July 8, 2012. The death toll from severe flooding in the Black Sea region of southern Russia has risen to at least 150. (AP Photo/Ignat Kozlov)

Local residents stand next to a bunch of garbage with a portrait of Russian President Vladimir Putin at a flooded house in Krimsk, about 1,200 kilometers (750 miles) south of Moscow, Russia, Sunday, July 8, 2012. The death toll from severe flooding in the Black Sea region of southern Russia has risen to at least 150. (AP Photo/Ignat Kozlov)

A man removes rubbish from a shop in Krimsk, about 1,200 kilometers (750 miles) south of Moscow, Sunday July 8, 2012. Intense flooding in the Black Sea region of southern Russia killed at least 150 people after torrential rains dropped nearly a foot of water, forcing many to scramble out of their beds for refuge in trees and on roofs, officials said Saturday. (AP Photo/Sergey Ponomarev)

A man walks along a flooded playground at the city stadium in Krimsk, about 1,200 kilometers (750 miles) south of Moscow, Sunday, July 8, 2012. Intense flooding in the Black Sea region of southern Russia killed at least 150 people after torrential rains dropped nearly a foot of water, forcing many to scramble out of their beds for refuge in trees and on roofs, officials said Saturday. (AP Photo/Sergey Ponomarev)

Russian President Vladimir Putin, background, heads a meeting to discuss flooding in southern Russia in Moscow on Monday, July 9, 2012. Authorities failed to properly warn residents in the Black Sea region of floods that killed at least 171 people and left others scrambling for safety, Russia's emergencies minister acknowledged Monday, adding to outrage over the handling of the disaster fueled by widespread mistrust of the government. (AP Photo/RIA Novosti Kremlin, Mikhail Klimentyev, Presidential Press Service)

(AP) ? The floods that washed through southern Russia and killed 171 people followed storms that dumped five months of rain in a matter of hours. Still, President Vladimir Putin has spent three days trying to persuade residents that the flooding was an act of nature and not the result of government negligence or worse.

Some persist in believing, against all evidence, that the city of Krymsk and its 57,000 people were intentionally sacrificed to prevent the flood waters from damaging Novorossiysk, a major Black Sea port essential for exporting Russian oil and grain.

This deep distrust of the government poses a challenge to Putin, who depends on the support of ordinary Russians across the country to counter the growing challenge in Moscow to his 12-year rule.

At the very least, the flooding has Russians once again questioning the government's ability to keep them safe. Still fresh in their memory are a string of disasters ? from the bungled response to the sinking of the Kursk submarine in 2000, to the wildfires that swept seemingly unopposed through a swath of western Russia in 2010, to the capsizing of an overloaded river boat that killed more than 120 people last year.

The Emergencies Ministry acknowledged Monday that it had failed to warn residents about the flash flood that turned Krymsk streets into swirling muddy rivers and filled one-story homes practically up to the ceiling in the middle of the night. Many of the 171 who died were elderly residents unable to escape in time.

A total of 29,000 people in Krymsk and the seaside resort town Gelendzhik lost all of their possessions, while about 300 homes in Krymsk and 100 in Gelendzhik were damaged beyond repair, according to government figures released Monday.

After torrential rains dropped up to 300 milliliters (12 inches) of water late Friday and early Saturday, the flooding inundated Krymsk so quickly that that residents said they suspected that water had been intentionally released from a reservoir in the mountains above the city to prevent the dam from being breached.

The suspicion was that this had been done to protect the Novorossiysk port, which is part-owned by the government and Transneft, the state monopoly that runs the oil pipeline system. The reservoir lies in mountains situated between Novorossiysk and Krymsk. It was unclear whether the port was in any danger.

The government denied the sluices had been opened and, in an effort to convince the skeptics, the Krasnodar region governor arranged for a group of residents to fly over the reservoir in a helicopter. He even arranged a second flight over a wider area after they complained that they had not seen enough the first time. Two members of the group were shown on television saying they were now convinced that the reservoir had not been the source of the flooding.

This was the same conclusion reached by a well-known local environmentalist, Suren Gazaryan, who has opposed the governor on other issues. Gazaryan studied the area around the reservoir and the high-water marks along a network of mountain streams, posting the photographs and his conclusions on his blog.

Still, prominent Moscow journalist Oleg Kashin, who was in Krymsk, said on Kommersant FM radio that none of the residents he had spoken to believed it was the weather alone that caused the flooding.

"It's not that the government's version of the events differs from that of the victims, but the thing is that it's normal in Russia to distrust authorities in everything ? be it a natural disaster, elections or soccer," Kashin said. "I'm sure that Krymsk will get repaired, compensations will be paid and the dead will be buried. But you have to agree that this will not make this crisis of confidence go away."

Early in his presidency, Putin learned the hard way about the need to take charge quickly when disaster strikes.

After two explosions sank the Kursk nuclear submarine in the Barents Sea on Aug. 12, 2000, Putin did not interrupt his vacation and the bewildered navy command hesitated for hours before launching a search. What little time was left for 23 sailors who had managed to flee to a rear compartment was wasted, and by the time Russia finally accepted help from Norwegian divers all 118 members of the crew were dead.

Throughout the crisis, naval officials issued a string of contradictory information about what sank the Kursk and the fate of the crew, much of it soon revealed to be untrue.

Since then, Russia has seen a series of natural and man-made disasters, many of them blamed on aging infrastructure, bad management or lax safety rules. But rather than let them dent his image, Putin has used the crises to show his command of the situation and his concern for the people who have suffered.

When wildfires swept across western Russia in 2010, Putin traveled to scorched villages, where he consoled weeping women and promised that their houses would be rebuilt. He also threatened to oust local officials who didn't do enough to fight the fires or help those who lost their houses.

This weekend, Putin flew immediately to Krymsk, where he viewed the damage and issued a series of orders to regional and federal officials. He promised that all the destroyed homes would be rebuilt and spelled out how much compensation each resident would receive.

He did not, however, meet with any of the people who were struggling to clean the mud out of their homes or who had lost an elderly parent to the flood, apparently unwilling to risk becoming a target of their anger.

Instead, Putin sent Gov. Alexander Tkachev to face the heat. When Tkachev tried to explain the cause of the flood to a crowd of people gathered in a city square, they shouted, "We don't believe you."

Ever since tens of thousands of protesters began marching through the streets of Moscow this winter chanting "Russia without Putin" and "Putin is a thief," he has had reason to be wary of people in the capital. His support, still at about 60 percent nationwide, has rested on people in places such as Krymsk who believe they can count on him to protect them.

On Monday, Putin held more televised meeting with officials. He demanded that investigators and the Emergencies Ministry give him a full report by the weekend on the causes of the flood and how its aftermath was handled.

___

Lynn Berry reported from Moscow. Nataliya Vasilyeva in Moscow also contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-07-09-EU-Russia-Flooding/id-1df5cbd1dff64291bcac96c2c48f425e

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Casino mogul gives $1M to new 'super' PAC (The Arizona Republic)

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Sunday, July 8, 2012

Ummm Hi

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Uhhh hi i went to the RP Forum and it said if i'm new that i should come here to meet new people...So umm hi my names Jake

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Saturday, July 7, 2012

Romney campaign's missteps have some Republicans grumbling

WASHINGTON (Reuters) - For months, Republican Mitt Romney's presidential campaign was a picture of discipline, charting a relatively steady course for the former Massachusetts governor through a bitterly contested primary season.

In recent weeks, however, Romney's tight ship has not looked so tight.

Romney's missteps on issues such as immigration and healthcare - and images of him on a jet ski during a vacation at his New Hampshire estate this week - have exasperated some supporters who are calling for a shake-up of his staff and worrying he could bungle Republicans' chances of ousting Democratic President Barack Obama in the November 6 election.

The concerns were summarized in an editorial late on Wednesday by The Wall Street Journal, which said Romney's Boston-based staff was "slowly squandering an historic opportunity."

"Mr. Obama is being hurt by an economic recovery that is weakening for the third time in three years," said the Journal, whose editorial page is a barometer of the thinking of leading conservatives. "But Mr. Romney hasn't been able to take advantage, and if anything he is losing ground."

The anxiety over Romney's campaign has been heightened this week by its conflicting messages over his position on a key part of the Supreme Court's ruling that upheld Obama's healthcare overhaul. But it was only the latest example of message problems from a campaign that even some Republicans say is being outmaneuvered by Obama's team.

Last month, Romney struggled to articulate a detailed response to Obama's executive order that stopped deportations of thousands of children of illegal immigrants.

The Republican - who trails Obama badly among Latino voters - still has not come up with an immigration plan that might cut into Obama's lead among Hispanics without angering Romney's conservative base.

Romney's decision to take this week off at his lakeside home in New Hampshire - which led to the photographs of the multi-millionaire zipping around on a jet ski with his wife, Ann - prompted some fellow Republicans to say that Romney had blown a chance to strike a more patriotic theme around the nation's July 4 Independence Day holiday on Wednesday.

Instead, some said, Romney fed a narrative being pushed by Obama's campaign: that the wealthy Republican is out of touch with the concerns of most other Americans, particularly the middle-class voters both candidates covet.

"I don't even think this is his fault," conservative radio talk host Laura Ingraham said. "This is his advisers. This is not Romney, this is the advisers telling him: 'Oh, it's fine. Take a week.' There's no week to spare, we have a country to save."

A TAX, OR A PENALTY?

Of particular concern to conservatives was Romney's policy dance this week over whether requiring Americans to buy health insurance under Obama's healthcare plan should be considered a tax, as the Supreme Court ruled last week, or a penalty.

Although Republicans were disappointed when the high court upheld the healthcare law last week, they took some solace in the court majority's declaration that the fee charged to those who refuse to buy health insurance was allowed under Congress' taxing powers - making the fee a tax.

That allowed Republicans to campaign on the notion that the Obama plan's "individual mandate" amounted to a tax increase.

But on Monday, Romney senior adviser Eric Fehrnstrom said that Romney believed the Obama healthcare law carried a "penalty," not a tax as the high court had ruled.

Fehrnstrom added that under a similar healthcare plan for Massachusetts that Romney backed as governor, the fee charged to those without coverage was considered a penalty, not a tax.

That put Romney squarely in opposition to the view held by Republican leaders of Congress and many Republican voters. Some Republicans said that by continuing to discuss the healthcare ruling, Romney's team was reminding voters of his role in creating the Massachusetts plan - and diverting the campaign from its focus on jobs and the economy, which most Republicans see as Obama's biggest weakness.

On Wednesday, Romney seemed to change course in an interview with CBS.

"The Supreme Court has the final word, and their final word is that Obamacare is a tax," he said. "So it's a tax. They decided it was constitutional. So it is a tax, and it's constitutional."

Some conservative critics of the campaign reacted with dismay.

Conservative radio talk show host Rush Limbaugh told his listeners it was a waste of time for Romney to debate whether the mandate was a penalty or tax.

"If this keeps going this way, we're going to lose it all, folks," he said.

On Thursday, Romney adviser John Sununu defended the candidate's staff during an interview with CNN.

"I think it's a good staff and I think they demonstrated that during the primaries" by pushing a consistent message, said Sununu, a former New Hampshire governor and White House chief of staff under President George H.W. Bush.

Going forward, Sununu said, the campaign must "recognize that we're in a campaign mode where simple, tough, declarative sentences are required. This is not a campaign to be won on nuance, but to be won on making sharp distinctions with the failure of the Obama administration economically, the loss of jobs and the pain that Americans across the country are feeling."

CRITICS WEIGH IN

The Obama campaign has been pounding Romney on his tenure as a private equity executive at Bain Capital, accusing him of being involved in the outsourcing of U.S. jobs overseas. This strikes at the heart of Romney's argument that his business experience makes him a natural for the White House at a time of economic distress.

The Romney camp's defense against such attacks included a highly public yet failed effort to persuade The Washington Post to correct a news story on the issue, ensuring the Bain issue got even more coverage.

Such moves led some conservatives to call for a campaign staff shake-up even before this week's flap over the healthcare law. Media mogul Rupert Murdoch led the appeals, and was quickly backed by a tweet from former General Electric CEO Jack Welch, who referred to Obama's staff in Chicago:

"Hope Mitt Romney is listening to Murdoch advice on campaign staff..playing in league with Chicago polls..No room for amateurs."

On Thursday there did not appear to be any sign of changes in Romney's staff. Republican strategists noted that every campaign had ups and downs, and that the race between Romney and Obama remained close in voter surveys.

"Publicly chastising the campaign is certainly not a way to be helpful," strategist Dave Carney said.

An outside adviser to Romney's team said that the campaign's position on the healthcare law "ended up in the right place, but they never should've had anybody on staff out there saying the wrong thing or setting the wrong policy.

"It can be taken as a little sign of disarray," the adviser said, "but I think the big things are going pretty well."

(Editing by David Lindsey and Peter Cooney)

Source: http://news.yahoo.com/romney-campaigns-missteps-republicans-grumbling-022305984--business.html

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How I learned to shut up and listen to constructive criticism

The Weekly Challenge is a column that tackles self-improvement seven days at a time.

My knee-jerk reaction to receiving negative feedback has always been the immediate and aggressive pursuit of personal vindication. Like a rabid defence lawyer in the court of Me, I deflect, make excuses, question the aptitude of my accuser ??? anything to avoid taking responsibility for my actions. At least, this is what my dollar-store psychology degree tells me is going on. Before embarking on my quest to openly accept and learn from constructive criticism, I opted to get some advice from the experts.

More Related to this Story

  • My week of talking to every single stranger who crossed my path

  • How I showed my true colours and gave up makeup for a week

  • For a week I resolve to be positive

I consulted Christie Mann, a certified, professional leadership coach who teaches execs how to give and receive feedback in a way that is beneficial to both parties. ???It might sounds corny, but the first thing you need to realize is that receiving well-intentioned, constructive feedback is a gift,??? she tells me, adding that the more we solicit feedback, the easier it is to receive. On the plus side, this means that simply by getting suggestions for self-improvement, I will be improving.

The best advice on how to actually receive criticism came from a friend who works as a defence attorney: ???Make eye contact and listen with your mouth shut. If you must open your mouth, it should be to say ???thank you.??? ??? Extreme, perhaps, but this bit of seemingly obvious advice helped enormously in terms of getting out of my own way. Shut up and listen became my secret mantra.

Memoirs of a defensive daughter

My mom, two sisters and I get together weekly to eat good food and watch The Bachelorette. Last week, I asked each of them to bring a piece of constructive criticism regarding how I might be a better daughter and sister. Interestingly, most of the feedback dealt with my ability (or inability) to take feedback. ???You tend to get very emotional and it becomes difficult to have a reasonable discussion with you,??? my sister Cynthia said. This was a surprise, since I view her as the emotional one. (I???d expected she???d say something how domineering and bossy I am.)

Normally I would have leapt to my own defence immediately. Instead I stuck to the rules ??? shut up and listen, shut up and listen ??? reminding myself that this exercise was not about what my sister does, and also that obviously she is (if you???ll pardon the Oprah-speak) expressing her truth. My mom???s critique was that I don???t really listen when someone has a differing viewpoint. I would disagree, but that just seems silly.

To get some professional feedback I consulted an editor who I have worked with for several years. He said that I need to put more time and effort into time management, so that I don???t miss deadlines. This is not news (my Grade 6 French teacher once wrote ???Courtney is disorganized??? on the blackboard as some sort of shaming exercise), but it presented a great opportunity to think about the second step of the constructive criticism journey: setting a specific post-criticism action plan. In a world of unlimited cash flow, I???d hire a life coach to whip me into shape. Instead, I hold a 20-minute time management meeting with myself every morning.

The Odd Couple: Chips and dip edition

The most easily addressed critical interaction of the week happened when I asked one of my closest friends if there was anything I could do to improve our relationship. In a very sweet and thoughtful e-mail, she offered myriad reasons why I am the best friend ever, and then told me that she would really like it if I made an effort to be more aware of our differing standards of cleanliness.

I learned that she is silently uncomfortable when I eat communal food (guac and chips, for example) without washing my hands. For almost 20 years, we have maintained a certain Oscar-and-Felix dynamic, with her regularly asking me to take my flip-flopped feet off the couch and me accusing her of low-level OCD. I viewed this as a fun aspect of our relationship, but after finding out that she was legitimately distressed, I was more than happy to accommodate. So far, more vigilant pre-snack handwashing has not caused any discomfort on my end.

When I began this experiment, I was secretly skeptical of whether I would learn anything, confident that I had a pretty good sense of my many flaws. In some cases this was true (my boyfriend raised the issue of cleaning up around the house, which I look forward to tackling head-on in next week???s challenge), but I was also made aware of certain behaviour patterns that I am more than happy to abandon. In the future I will try to not let self-defence get in the way of self-improvement. Or at least I will shut up and listen before I start building my case.

Reader Response

If it???s actual constructive criticism, delivered correctly, then no one should have an issue with it. It???s when people criticize badly that it gets people???s back up.

??? Fiona Kelly

I think it???s about confidence, having an open mind and welcoming self-improvement. And that clich? of not just hearing someone, but listening to what they are saying.

??? Nancy Saunders

I think its about ambition. If you really want to move up, you cant assume you have what it takes right now. Sometimes you have to build yourself up a bit, and to do so you cant have too much pride!

??? Andrew Hanna

Next Challenge

Banish casual procrastination! Tune out the little voice that says ???I???ll get to it later.??? Instead, tackle every single task that arises, providing it can be done in two minutes or less. Change a light bulb as soon at it goes out, don???t leave empty takeout containers on the counter and, for heavens sake, put the lid back on the toothpaste! So often we stress over the hundred tiny tasks on the to-do list. Imagine how much more time you???d have if you took care of the small stuff as it arises.

Sign up at fb.com/globelifestream to tell us how it went.

Special to The Globe and Mail

article source

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Source: http://www.debtowed.info/?p=2183

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Friday, July 6, 2012

Serbs Hope to Win Elections in Srebrenica :: Balkan Insight

Putting their political differences aside, all nine Bosnian Serb parties have decided to support one candidate, Vesna Kocevic, who is currently in charge of economic policy in the municipality of Srebrenica.

The changes to the electoral law mean that voting in the town of Srebrenica, which is in the predominantly Serb entity of Republika Srpska, will be conducted according to the rules that apply to the rest of Bosnia, so the voting should now be based on place of residence.

Until this year, voting in Srebrenica took place according to the 1991 census, when Srebrenica had a predominantly Bosniak population.

Following the 1995 massacre of more than 7,000 Bosniak men in the town of Srebrenica by the Bosnian Serb army, most local Bosniaks were either killed or left the city, which make the city predominantly settled by Serbs.

Vesna Kocevic argues that since the Bosniaks have been able to elect a mayor from their own ethnicity for the past ten years, the time has come for the Serbs to have their own representative.

??We are sorry for what happened in Srebrenica during the war, and we are sorry that a lot of people left our town. We respect the decisions of the courts regarding genocide, but we do not think that all Serbs living there should be treated differently, since the crimes were committed by individuals and not the nation,? says Kocevic.

?We live together with the Bosniaks, we have a high level of tolerance in the town, and we simply want a mayor of Serbian ethnicity,? adds Kocevic.

According to the current data of the Srebrenica Municipality, around 12, 000 people have the right to vote. 8,000 of the voting population are Serbs, and the rest Bosniaks.

Dragan Glisic, the director of the Archeology Museum in Skelane and a member of the Serb coalition election committee, says that despite the pressures from both Bosniaks and the international community, the Republika Srpska authorities have fought against the idea that the electoral law in Srebrenica should be any different to that of other Bosnian towns.

Glisic also condemned the abuse of the electoral system in Srebrenica by political actors on both sides, including the recent announcement by the Serbian Mufti [Muslim religious leader] Muamer Zukorlic that he will register his place of residence as Srebrenica, so that he can vote there.

Bosniaks are worried that the next mayor of Srebrenica could come from a party which does not recognize the Srebrenica genocide.

Both Bosniak and Bosnian Serb parties hope to strengthen their chances in the elections by uniting on the basis of ethnic background. Both sides have called upon all those who were originally resident in Srebrenica but no longer live there to register to vote

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Source: http://www.balkaninsight.com/en/article/serbs-hope-to-win-elections-in-srebrenica

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